Characterization of preneoplastic lesions and stratification of their evolving risks

Presentation

One of the key areas of the 2021 – 2030 Ten-Year Strategy for Cancer Control focuses on cancer prevention. In this context, Inserm wishes to continue its support for the development of research in the field of precision prevention by reiterating a call for projects aimed at characterizing pre-neoplastic conditions and better stratifying their evolutionary risks.

Objectives of the call

Study of pre-neoplastic lesions — either paediatric or adult — defined as precancerous states at the cellular level, for which there is clear evidence of an association with an increased risk of cancer, or which share molecular and phenotypic characteristics with an aggressive type of cancer. The goal is to contribute to a better understanding and modelling of their evolution (transition from pre-malignant to malignant, stabilization, regression) by characterizing the underlying mechanisms, the sequence of formation, and the factors involved in the emergence and evolution of the risk, to stratify pre-neoplastic lesions based on their risk of progression and to identify intervention targets.

Special characteristics

• The project should include 2 to 4 teams, with at least one team involving clinicians. The involvement of pathologists is highly recommended.
• Each team can submit only one application (regardless of the role : Project Coordinator or Partner).

Call

Related

• Chair in Paediatric Oncology Research
• Characterization of preneoplastic lesions and stratification of their evolving risks
• Contributions of physics, chemistry and engineering sciences to oncology (PCSI)
• Contributions of mathematics and computer science to oncology (MIC)