Characterization of preneoplastic lesions and stratification of their evolving risks

Presentation

Objectives

Study of pre-neoplastic lesions (either paediatric or adult) defined as precancerous states at the cellular level, for which there is clear evidence of an association with an increased risk of cancer, or which share molecular and phenotypic characteristics with an aggressive type of cancer. The goal is to contribute to a better understanding and modelling of the evolution of these preneoplastic lesions (transition from premalignant to malignant, stabilization, regression) by characterizing the underlying mechanisms, the sequence of their formation, and the factors involved in the emergence and evolution of risk. This will allow for stratification according to their risk of progression and identification of intervention targets.

Specificities

• The projects must involve 2 to 4 teams from at least two different disciplines, with at least one team involving clinicians. The presence of one or more pathologists is highly recommended
• The same project cannot be submitted to Inserm’s 2025 calls for proposals “Interdisciplinary approaches to oncogenic processes and therapeutic perspectives : Contributions of physics, chemistry and engineering sciences to oncology (PCSI) » or « Contributions to oncology from mathematics and computer science (MIC). »
• Each research team may submit only one proposal (regardless of its role : project coordinator or partner in a consortium).

Call

Related

• Chair in Paediatric Oncology Research
• Characterization of preneoplastic lesions and stratification of their evolving risks
• Contributions of physics, chemistry and engineering sciences to oncology (PCSI)
• Contributions of mathematics and computer science to oncology (MIC)